Steve Chamberland recently received an invitation to speak at the Small Splash, Big Waves symposium at the Fall 2015 national meeting of the American Chemical Society. This symposium, offered by the American Chemical Society Division of Organic Chemistry, is designed to highlight the research successes that can be achieved at primarily undergraduate institutions. This is the first invited seminar at the national level for Dr. Chamberland. He will speak at the fall ACS meeting in Boston, MA about the group’s research over the last few years and what’s coming on the horizon. Congratulations to the current and former group members whose achievements made this opportunity possible, and to Central Washington University for providing a platform for launching our successful research program.
Chris Malmberg’s abstract entitled “Total synthesis of clavatadine A analogues to produce a viable reversible inhibitor of factor XIa” was accepted by the American Chemical Society Division of Medicinal Chemistry. Chris will present his poster at the Spring 2015 national meeting of the ACS in Denver this March. Congratulations Chris! If you go to the meeting, please visit his poster on Sunday evening, March 22, 2015.
Since 2010, our group has been working hard to complete the first total synthesis of clavatadine A, a chemical that is a natural blood coagulation inhibitor. Our group completed the total synthesis in November 2013, and then quickly wrote and submitted the paper for publication in December of that year. Reviewers universally recommended acceptance of the manuscript once key enzyme inhibition data was gathered on our synthesized compound. Without the ability to do this work at CWU, I reached out to Dr. Ronald J. Quinn of the Eskitis Institute of Griffith University in Brisbane, Australia. Dr. Quinn first isolated clavatadine A from the ocean sponge Suberea clavata in 2008. We collaborated with Dr. Quinn and a postdoctoral researcher in his group, Dr. Rebecca N. Pouwer. In October 2014, the enzyme inhibition data from Dr. Quinn and Dr. Pouwer revealed that the synthetic compound bound to the target coagulation factor with almost exactly the same affinity as the natural compound, which paved the way for the paper to be published, finally. After almost a year of waiting since we submitted the paper, it appeared online today on the Journal of Natural Products website (see our Publications section). For a small research group at a regional teaching college, this is a big accomplishment. I thank my former research students and co-authors Stephanie Conn, Shannon Huffman (nee Vreeland), and Alexandra Wexler, without whom this work would not have been possible. Working with dedicated and talented students and scientists like Stephanie, Shannon, and Alex makes my job worthwhile. I also thank Dr. Quinn and Dr. Pouwer. We’ve never met, but I hope to make your acquaintance on my next trip to Australia. Cheers! -SC
This website will always be a work in progress, but its mission is to publicize the great work and achievements of our talented group members.
Our research is guided by our Mission Statement
The Chamberland Group seeks to develop quality scientists. We race to be the first to synthesize new, biologically active molecules. Procedures we develop and modify will be robust, repeatable, and well documented. Victory is achieved by initiative, creativity, attention to detail, and most of all, hard work. It pays to be a winner.