Clavatadine C, D, and E total synthesis paper submitted!

Congrats to Kylee Maxfield and Morgan Payne for their contributions to our recently completed research article, which we uploaded to the preprint server ChemRxiv (pronounced “Chem-ar-KIVE” at the following link:

Total Synthesis and Biological Evaluation of Clavatadines C-E

Although this version of the paper was not peer reviewed, we also submitted it to a reputable journal in the field to undergo peer review, and I’ll post an update once it gets published. By far, this was the longest paper I’ve written, and the first to include National Cancer Institute NCI-60 screening data on our synthesized compounds. All told, it was a herculean effort. Much credit goes to the students who devoted so much of their time in the lab and in the NMR instrument room to make it all happen. Thanks also to the sabbatical leave I was given this year, which enabled me to spend an enormous amount of time in the lab free of teaching duties.


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