Congratulations to UVU graduates Michael Davenport, Jordan Dickson, and Matthew Johnson! Each earned their first peer-reviewed publication in the Journal of Natural Products. We report the first total synthesis of clavatadine B, a natural inhibitor of human blood coagulation factor XIa. Though it is not as potent as the clavatadine A congener, its synthesis was achieved using a similar direct, early-stage guanidinylation approach. The total synthesis originated from the same dibrominated precursor that was used to make clavatadine A, which made the total synthesis four-steps long. It is six steps from commercially available materials.
Read our paper here: Total Synthesis of Clavatadine B