Clavatadine B total synthesis in the Journal of Natural Products

Congratulations to UVU graduates Michael Davenport, Jordan Dickson, and Matthew Johnson!  Each earned their first peer-reviewed publication in the Journal of Natural Products.  We report the first total synthesis of clavatadine B, a natural inhibitor of human blood coagulation factor XIa.  Though it is not as potent as the clavatadine A congener, its synthesis was achieved using a similar direct, early-stage guanidinylation approach.  The total synthesis originated from the same dibrominated precursor that was used to make clavatadine A, which made the total synthesis four-steps long.  It is six steps from commercially available materials.

Read our paper here:  Total Synthesis of Clavatadine B


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